The sensitivity of Pseudomonas pseudomallei to trimethoprim and sulphamethoxazole in vitro.
نویسنده
چکیده
Twelve out of 14 strains of Pseudomonas pseudomallei were inhibited in vitro by a combination of trimethoprim 1 mug per ml and sulphamethoxazole 20 mug per ml or by lower concentrations. Of the remaining strains, one was marginally more resistant and one was distinctly so. In tests utilizing two of the sensitive strains, inhibitory concentrations of the individual drugs exerted a bactericidal effect when combined.
منابع مشابه
Simulataneous Analysis of Trimethoprim and Sulphamethoxazole Drug Combinations in Dosage Forms by High Performance Liquid Chromatography
A sensitive high performance liquid chromathography (HPLC) analytical procedure was developed for the quantitive determination of trimethoprim (TM* and sulphamethoxazole (SM) in commercial dosage forms. C18 analytical column (stainless steel, 25 cm * 4.6 mm i.d.) was packed with 5-*m particles of the reversed phase material and used for assays. Mobile phase containing 0.025 M sodium phosphate...
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 24 9 شماره
صفحات -
تاریخ انتشار 1971